RUKOBIA, as part of an HIV-1 treatment regimen, may help reduce your viral load if your current HIV-1 treatment is no longer working.

WHAT IS RUKOBIA?

RUKOBIA is an HIV-1 treatment that works differently from other HIV-1 treatments by stopping the virus from attaching to your CD4+ T-cells.

RUKOBIA is not for use alone. RUKOBIA will be given along with an HIV-1 treatment regimen recommended by your doctor.

RUKOBIA is proven to help decrease viral load in some people whose virus is still detectable despite having exhausted many other treatment options.

Results may vary.

Ask your doctor what RUKOBIA could mean for you.

HOW DO I TAKE RUKOBIA?

One 600-mg tablet
Tablet shown is not actual size

Taken twice daily around the same time each day

With or without food

  • Swallow tablets whole. Do not chew, crush, or split tablets

How RUKOBIA
Can Help You

See how RUKOBIA may help you reach your treatment goals.

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Accessing RUKOBIA

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STUDY RESULTS

In a clinical study of 371 adults with HIV-1, RUKOBIA was added to a treatment regimen and was evaluated at Day 8, 24 weeks, and 96 weeks.

People who entered the study met the following criteria:

  • The virus was detectable while on their current regimen (viral load greater than or equal to 400 copies/mL)
  • The virus was resistant to many HIV-1 treatments
  • They had limited treatment options (no more than 2 antiretroviral classes remaining)

The study included people with advanced HIV-1:

89%

had viral load greater than 1000 copies/mL

75%

had CD4+ T-cells* less than 200 cells/mm3

86%

had history of AIDS

30%

had CD4+ T-cells less than 20 cells/mm3

*CD4+ T-cells (also called T-cells) are white blood cells that help fight infections. CD4+ T-cell count is the number of CD4+ T-cells per mm3 of blood.

AIDS=acquired immune deficiency syndrome.

Viral load decreased after 8 days

During the first 8 days of the study, people were randomly selected to receive either RUKOBIA or a sugar pill added to their current regimen. After 8 days, the average viral load decrease was evaluated.

At Day 9, all people still on their current regimen were changed to RUKOBIA along with a tailored treatment regimen that best fit the needs of each person for the remainder of the study.

Results may vary.

Calculated from viral load changes: -0.79 log10 (RUKOBIA + current regimen) and -0.17 log10 (sugar pill + current regimen).
The tailored treatment regimen was based on the needs of each person and the number of active antiretroviral therapies remaining to replace their current regimen, which had stopped working.

Some people reached undetectable and remained undetectable at 96 weeks

More than half of the 272 people who took RUKOBIA with a tailored treatment regimen reached undetectable by 24 weeks and remained undetectable at 96 weeks.

People Who Reached Undetectable

  • Undetectable means reducing the HIV in your blood to very low levels
  • In the study, undetectable was defined as less than 40 copies/mL

Results may vary.

Increased CD4+ T-cell counts*

As part of a tailored treatment regimen, RUKOBIA increased and maintained the number of infection-fighting CD4+ T-cells in the immune system.

AVERAGE INCREASE IN CD4+ T-CELL COUNTS

  • In people with a low CD4+ T-cell count below 20 cells/mm3 at the start of the study, RUKOBIA, added to a tailored treatment regimen, helped increase CD4+ T-cells by more than 200 cells/mm3 on average

Results may vary.

What were the most common side effects?

The most common side effect through 96 weeks, reported by 5% or more of people, was nausea (10%).

  • 5% of people stopped taking RUKOBIA because of adverse events

Results may vary.

What are the possible side effects of RUKOBIA?

RUKOBIA can cause serious side effects including:

  • Changes in your immune system (Immune Reconstitution Syndrome)
  • Heart rhythm problems (QTc prolongation)
  • Changes in liver function blood tests results

These are not all the possible side effects of RUKOBIA. Always tell your doctor if you experience any side effects.

Living with HIV and interested in sharing your story?

If you are 18 years or older, please call 1-888-203-9565 to find out more about this opportunity.

Possible Side Effects

Learn what side effects to look out for when taking RUKOBIA.

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