“RUKOBIA, in conjunction with the other antiretrovirals I'm taking, got me to undetectable. And I've stayed there.” 

Results may vary.

 

Dennis, taking RUKOBIA as part of an HIV-1 regimen.
Compensated by ViiV Healthcare.

Results with RUKOBIA

RUKOBIA could make the difference

RUKOBIA may help reduce the HIV viral load for people with no or limited options left.

In a ~5 year clinical study of 371 adults with HIV-1, RUKOBIA was added to their other HIV medicines and was evaluated at Day 8, Weeks 24, 96, 240.

People who entered the study met the following criteria:

  • The virus was detectable while on their current medicines (viral load greater than or equal to 400 copies/mL)
  • The virus was resistant to many HIV‍‍-‍1 treatments
  • They had limited treatment options (no more than 2 antiretroviral classes remaining)

The study included people with advanced HIV‍‍-‍1:

  • 89% had viral load greater than 1000 copies/mL
  • 75% had CD4+ T-cells* less than 200 cells/mm3
  • 86% had history of AIDS
  • 30% had CD4+ T-cells less than 20 cells/mm3

*CD4+ T-cells (also called T-cells) are white blood cells that help fight infections. CD4+ T-cell count is the number of CD4+ T-cells per mm3 of blood.

AIDS=acquired immune deficiency syndrome.

A ~5 year clinical study showed that

A ~5 year clinical study showed that

RUKOBIA may help you reach and stay undetectable

Viral load decrease*:

viral load decrease chart

At Day 9, all participants still on their current medicines were changed to RUKOBIA along with other medicines† that best fit the needs of each person for the remainder of the study.

 

Results may vary.

*Calculated from viral load changes: -0.79 log10 (RUKOBIA + current medicines) and -0.17 log10 (sugar pill + current medicines).

†The other medicines were based on the needs of each person and the number of active antiretroviral therapies remaining to replace their current medicines, which had stopped working.

Some people reached undetectable and remained undetectable through ~5 years* 

More than half of the 272 people who took RUKOBIA along with other treatment medicines1 reached undetectable by 24 weeks and 45% remained undetectable at Week 240

  • Undetectable means reducing the HIV in your blood to very low levels
  • In the study, undetectable was defined as less than 40 copies/mL

*Results may vary

Average CD4+ T-cell count increased over time.

Results may vary

Some participants had improved CD4+ T-cell counts on RUKOBIA*

With other treatment medicines, RUKOBIA helped to increase the number of infection-fighting CD4+ T‍-‍cells in the immune system

AVERAGE INCREASE IN CD4+ T-CELL COUNTS FROM DAY 0

CD4 cell count

*Results may vary

Participants who started the study with very low CD4+ T-cell count (below 20 cells/mm³) had similar CD4+ recovery as the overall group, with an increase of more than 200 cells/mm³ on average through Week 240


Results may vary

Learn more about taking RUKOBIA

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